Host Genetic Factors in HIV Transmission and Disease Progression  WEAA01

Oral Abstract Session Back
Venue: SR 6 (450)
Interpretation: None
Time: 11:00 - 12:30, 06.08.2008
Code: WEAA01
Co-Chairs: Carole Devaux, Luxembourg
Mark J. Mulligan, United States

Presentations in this session:

Mark J. Mulligan, United States

200 novel candidate human proteins needed for HIV-1 replication revealed from a comprehensive shRNA-targeted screening in Jurkat cells
Presented by Kuan-Teh Jeang, United States
P. Yeung, V. Yedavalli, K.-T. Jeang
NIH, NIAID, Bethesda, United States

Predominance of a heterozygous hCCR5delta24 deletion in HIV-exposed noninfected partners of HIV-serodiscordant couples and in long term survivors in Rwanda
Presented by Carole Devaux, Luxembourg
C. Devaux1, C. Masquelier1, M. Lemaire1, F. Baatz1, G. Iserentant1, J.C. Karasi1, D. Perez Bercoff1, E. Karita2, S. Allen2, V. Arendt3, J.C. Schmit1
1CRP Santé, Retrovirology, Luxembourg, Luxembourg, 2Emory University, Rwanda-Zambia HIV Research Group, Atlanta, United States, 3Centre de Recherche Hospitalier, Maladies Infectieuses, Luxembourg, Luxembourg

Association of -592C/A, -819C/T and -1082A/G interleukin-10 promoter polymorphisms with risk of HIV-1 infection among North Indians
Presented by Animesh Chatterjee, India
A. Chatterjee1, A. Rathore1, P. Sivarama2, N. Yamamoto3, T.N. Dhole1
1SGPGIMS, Microbiology, Lucknow, India, 2AIDS Counseling and Treatment Center, Belgaum, India, 3Nagoya University, International Health, Nagoya, Japan

Maternal human leukocyte antigen-A*2301 and A*0201 are associated with increased mother-to-child HIV-1 transmission
Presented by Romel D. Mackelprang, United States
R.D. Mackelprang1, G. John-Stewart2, M. Carrington3, B. Lohman-Payne4, B. Richardson5, M. Majiwa6, C. Farquhar2
1University of Washington, Department of Epidemiology, Seattle, United States, 2University of Washington, Departments of Medicine and Epidemiology, Seattle, United States, 3NCI-Frederick, Laboratory of Genomic Diversity, SAIC-Frederick, Inc., Frederick, United States, 4University of Washington and University of Nairobi, Departments of Medicine and Paediatrics, Nairobi, Kenya, 5University of Washington, Department of Biostatistics, Seattle, United States, 6University of Nairobi, Department of Paediatrics, Nairobi, Kenya

Repression of HIV-1 LTR promoter by nuclear matrix protein SMAR1 promotes proviral latency
Presented by Kadreppa Sreenath, India
K. Sreenath1, L. Pavithra1, S. Singh1, U.K. Ranga2, S. Chattopadhyay1
1National Centre for Cell Science, Pune, India, 2Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India

Rapporteur report

Track A report by Guido Silvestri

This interesting session focused on the role of host genetic factors in HIV transmission and pathogenesis. This is an area of HIV/AIDS research that is rapidly evolving over the past few years, and may have a tremendous impact on both understanding the mechanisms of HIV action and identifying new targets for antiviral therapies. Dr. Jeung () used a library of small inhibitory RNA (siRNAs) to transduce Jurkat cells and then screen for cellular proteins whose expression is required for HIV replication. With this assay Dr. Jeung and his colleagues identified >200 genes—and then validate their role using stably siRNA transfected cell lines. Dr. Devaux described a new, albeit rare, CCR5 mutation (hCCR5D24 mutation) that may protect from HIV infection and disease progression. Dr. Mackelprang reported the effect of HLA-A*2301 allele in favoring vertical transmission of HIV (while the A*7401 and B*1801 alleles may protect)—thus confirming how the HLA class I genetic background profoundly influences the interaction between HIV and the host.



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