AIDS 2008 – Mexico City 3-8 August 2008 - XVII Internationnal AIDS Conference

Host Genetic Factors in HIV Transmission and Disease Progression	WEAA01

Organiser:

Type:

Oral Abstract Session

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Venue:

SR 6 (450)

Interpretation:

None

Time:

11:00 - 12:30, 06.08.2008

Code:

WEAA01

Co-Chairs:

Carole Devaux, Luxembourg
Mark J. Mulligan, United States

Presentations in this session:

11:00
WEAA0100 Introduction
Mark J. Mulligan, United States

11:05
WEAA0101
Abstract 200 novel candidate human proteins needed for HIV-1 replication revealed from a comprehensive shRNA-targeted screening in Jurkat cells
Presented by Kuan-Teh Jeang, United States
P. Yeung, V. Yedavalli, K.-T. Jeang
NIH, NIAID, Bethesda, United States

11:20
WEAA0102
Abstract Predominance of a heterozygous hCCR5delta24 deletion in HIV-exposed noninfected partners of HIV-serodiscordant couples and in long term survivors in Rwanda
Presented by Carole Devaux, Luxembourg
C. Devaux¹, C. Masquelier¹, M. Lemaire¹, F. Baatz¹, G. Iserentant¹, J.C. Karasi¹, D. Perez Bercoff¹, E. Karita², S. Allen², V. Arendt³, J.C. Schmit¹
¹CRP Santé, Retrovirology, Luxembourg, Luxembourg, ²Emory University, Rwanda-Zambia HIV Research Group, Atlanta, United States, ³Centre de Recherche Hospitalier, Maladies Infectieuses, Luxembourg, Luxembourg

11:35
WEAA0103
Abstract Association of -592C/A, -819C/T and -1082A/G interleukin-10 promoter polymorphisms with risk of HIV-1 infection among North Indians
Presented by Animesh Chatterjee, India
A. Chatterjee¹, A. Rathore¹, P. Sivarama², N. Yamamoto³, T.N. Dhole¹
¹SGPGIMS, Microbiology, Lucknow, India, ²AIDS Counseling and Treatment Center, Belgaum, India, ³Nagoya University, International Health, Nagoya, Japan

11:50
WEAA0104
Abstract Maternal human leukocyte antigen-A*2301 and A*0201 are associated with increased mother-to-child HIV-1 transmission
Presented by Romel D. Mackelprang, United States
R.D. Mackelprang¹, G. John-Stewart², M. Carrington³, B. Lohman-Payne⁴, B. Richardson⁵, M. Majiwa⁶, C. Farquhar²
¹University of Washington, Department of Epidemiology, Seattle, United States, ²University of Washington, Departments of Medicine and Epidemiology, Seattle, United States, ³NCI-Frederick, Laboratory of Genomic Diversity, SAIC-Frederick, Inc., Frederick, United States, ⁴University of Washington and University of Nairobi, Departments of Medicine and Paediatrics, Nairobi, Kenya, ⁵University of Washington, Department of Biostatistics, Seattle, United States, ⁶University of Nairobi, Department of Paediatrics, Nairobi, Kenya

12:05
WEAA0105
Abstract Repression of HIV-1 LTR promoter by nuclear matrix protein SMAR1 promotes proviral latency
Presented by Kadreppa Sreenath, India
K. Sreenath¹, L. Pavithra¹, S. Singh¹, U.K. Ranga², S. Chattopadhyay¹
¹National Centre for Cell Science, Pune, India, ²Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India

Rapporteur report

Track A report by Guido Silvestri

This interesting session focused on the role of host genetic factors in HIV transmission and pathogenesis. This is an area of HIV/AIDS research that is rapidly evolving over the past few years, and may have a tremendous impact on both understanding the mechanisms of HIV action and identifying new targets for antiviral therapies. Dr. Jeung () used a library of small inhibitory RNA (siRNAs) to transduce Jurkat cells and then screen for cellular proteins whose expression is required for HIV replication. With this assay Dr. Jeung and his colleagues identified >200 genes—and then validate their role using stably siRNA transfected cell lines. Dr. Devaux described a new, albeit rare, CCR5 mutation (hCCR5D24 mutation) that may protect from HIV infection and disease progression. Dr. Mackelprang reported the effect of HLA-A*2301 allele in favoring vertical transmission of HIV (while the A*7401 and B*1801 alleles may protect)—thus confirming how the HLA class I genetic background profoundly influences the interaction between HIV and the host.